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Gluconolactone and PHAs

We look for thisReviewed September 18, 2026

Gluconolactone · Polyhydroxy Acid · PHA · Lactobionic Acid

Polyhydroxy acids, the gentlest exfoliating acids available, with molecules too large to reach the nerve endings that make AHAs sting.

What it does
Actives & treatment
Our take
Where we'd start anyone who wants exfoliation but has sensitive, reactive or barrier-damaged skin. They also hold water, so they hydrate while they exfoliate, and unlike AHAs they don't meaningfully increase sun sensitivity.
What we look for
4-10%
Suitable from
Teen, 13+ · Young adult, 20+ · Middle aged, 40+
Best for
Dark marks & dullness · Dryness & hydration · Barrier repair · Aging & firmness
Skin types
Sensitive · Dry · Combination · Blemish-prone

What we read

  • Published PHA tolerability studies · reviewed Sep 2026

Every other ingredient, with the same treatment.

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